When haemoglobin unloads oxygen, its affinity for oxygen decreases. So it  should get progressively easier to release each oxygen molecule. However,  in reality, it gets progressively harder to unload the oxygen although

When haemoglobin unloads oxygen, its affinity for oxygen decreases. So it should get progressively easier to release each oxygen molecule. However, in reality, it gets progressively harder to unload the oxygen although

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